1. Using a low sample size:
a. start with low number of participants or
b. design a two phase study where a number of subjects get eliminated after first phase
2. If raw data analysis do not provide desired result, present results in ratios, relative frequencies etc., in order to show increased response rate among test material group when compared with placebo group.
http://www.truthinlabeling.org/Proof_Controversy_C.htm
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