HOW OBESITY LEADS TO CANCER?

According to 2018 February report of WHO, overweight population among adults over 18 in world is around 1.9 billion. Out of them, over 650 million are considered obese. Under mentioned figures represent 39% overweight with one third of this percentage obese.

The problem is not limited to adults. "41 million under 5 children are overweight and obese, while 340 million are overweight and obese out of 5 - 19 children and adolescents", WHO report says.

( Overweight is defined as 25 - 30 kg/m2 BMI, while above 30 kg/m2 BMI is defined as obesity).

According to American Institute for Cancer Research, a range of cancers are associated with obesity.

A latest review published in 2018 February, had revealed a biochemical pathway that can be possibly accounted for the infamous link. Trevor W. Stone, the lead author of review, says "Activation of chronic inflammatory pathways, specially kynurenine pathway affects feeding, metabolism and promotion of carcinogenesis". Endogenous, environmental and dietary serine proteases deplete tumor suppressor cells, contributing for the imbalance further.